Identify the following:
1. this type of refractometer is extensively used in pharmaceutical analysis because of its simplicity and ease of manipulation.
2. two of the basic principles upon which chromatographic separations is dependent on., aside form the ion-exchange & molecular exclusion.
3. a type of chromatography w/c uses inert gas, as the mobile phase
4. a solid adsorbent used as filter paper
5. a process in w/c a sol of a mixture contains an inert materials , drug principles
and impurities is separated into its component.
6.method in chromatography with greater speed, precision, accuracy & ease of
manipulation.
7. thin layer chromatography
8. the adsorbent used in thin Layer chromatography
9. two of the basic principles upon which chromatographic separations is dependent on.
10. commonly used to develop chromatograms
11. fingerpoint region in IR spectrometry
12..the heart & soul of HPLC & GC
13. # of tablets conducted in content uniformity test
14. assures that the oldest stock is used ist policy
15. absorbance is directly proportional to conc & pathlength
16. linear distance from any point of 1 wave to the corresponding point on the adjacent wave
17. refer to water suitable for drinking
18. measures the index of refraction of a chemical substance
19. .the dye used in leakers test
20. a molecule w/c provides groups of attachment to metal ions.
TRUE OR FALSE:
1 the statement method I of WCD in USP 27 is the ATDM. IS CORRECT
2 iodometry is an indirect analysis of oxidizing agent
3. when a reducing analyte is titrated directly with iodine, the method used is called IODIMETRY.
4. to keep samples moisture free, the appropriate apparatus to use is incubator.
5. the use of NaHCO3 in the standardization of iodine solution is: to inc the solubility
6. when a weak base is to be titrated with weak acid, the indicator used is methyl orange
7. indicator in redox titration using KMnO4 is starch.
8. most suitable indicator to use in the titration of organic acids is methyl red.
9. the equilibrium constant for the reaction of metal ion with a ligand is called solubility constant
10. a molecule w/c provides groups of attachment to metal ios is chelate
11. in the standardization of iodine solution, there is a need to boil the solution of arsenic trioxide to inc the solubility
12. the color of the complex resulting from reaction with ferrous phenanthroline is pink.
13. types of chemical reaction used in the volumetric analysis is diazotozation
14. if starch TS is used as an indicator, the end point is the appearance of intense blue color:
15. a substance w/c gains electrons in a redox reactiona is an oxidizing agent .
16. indicators used in non aqueous titrimetry is phenolphthalein.
17. standard solutions are also known as test solutions.
18.std. sol in non-aqueous titrimetric analysis-acidimetry perchloric acid
19. sodium carbonate is added to maintain the pH of sodium thiosulfate
in optimum range for the stability of the solution?:
20. a ligand that binds to a metal ion through only one atom.
a. monodentate b. bidentate c. tridentate d. tetradentate
Multiple Choice/Identification
1. methyl orange in base medium is colored:
a. colorless b. yellow c. pink d. green
2. titer is an expression of concentration in terms of :
a. g. per liter b. g or mg of solute per mL
3. analysis where separation of the constituents from the sample is done
and then weighing the product is:
a. volumetric b. gravimetric c. special
4. to keep samples moisture- free the apparatus used is:
a. dessicator b. incubator c. furnace
5. the type of ash where sulfuric acid is used to whiten the ash is:
a. acid insoluble ash b. sulfated ash c. loss on ignition
6. the oil from peppermint spirit can be determined by using:
a. cassia flask b. bobcock bottle c. pycnometer
7. the unsaponifiable matter present in animal fats is:
a. cholesterol b. phytosterol c. cellulose
8. the crude fiber of a drug usually consists of:
a. cellulose b. cholesterol c. phytosterol
9. hexane is the best solvent in extracting:
a. resins b. fats c. volatile oil
10. the instrument used to measure the optical activity of the sample is:
a. refractometer b. polarimeter c. spectrometer
11. Process of measuring the actual quantity of mass, volume, force, etc. that correspond to an indicated quantity on the scale of an instrument.
a. weighing b. calibration c. nota d. both a & b
12. residue on ignition is also called:
a. loss on ignition b.sulfated ash c. acid-insoluble ash
13. method I for determining alcohol-soluble extractives is also known as:
a. hot extraction b. cold extraction c. hot compressed d. cold
14. the type of alkaloidal assay where the total alkaloid is determined
a.proximate b.ultimate c. specific d. extraction
15. w/c of the following statement/s is correct?
I. in azeotropic method of water analysis, toluene is used as solvent
II. in AMOWA, toluene & xylene are used as solvents
III. in AMOWA, toluene, xylene, and water are used as solvents
a. I only b. I, II only c. I, II, & III d. NOTA
16. the 0.1N iodine solution is standardized using:
a. pot,. Permanganate b. arsenic trioxide c.sod. carbonate
17. the active fraction of starch w/c react with iodine to form an intense blue color is:
a. amylose b. amylopectin c. glucose d. sucrose
18. also known as eosin y.:
a. tetrabromofluorescein b. xylenol orange c.dichlorofluorescein
19. what is the use of HgI2 in the preparation of starch TS?
a. to increase the solubility of starch b. act as a preservative
20. primary standard used to standardize Karl Fischer reagent is :
a. sodium tartrate b. pot. Hydrogen phthalate
21. w/c of the following statement/s is /are correct:
I. method I of WCD in USP 27 is the ATDM.
II method II of WCD in USP 27 is the titrimetric method.
III method III of WCD in USP 27 is the gravimetric Method
IV .method IV of WCD in USP 27 is the Karl Fischer Method
a. I only b. II only c. III only d. IV only
22. iodometry is an indirect analysis of:
a. oxidizing agent b. reducing agent c. acid d. base
23. when a reducing analyte is titrated directly with iodine, the method used is called:
a. iodometry b. iodimetry c. cerimetry d. permangonometry
24. to keep samples moisture free, the appropriate apparatus to use is:
a. separatory funnel b. dessicator c. incubator
25. the use of sodium bicarbonate in the standardization of iodine solution is:
a. to increase the solubility b. as buffer c. as preservative
26. when a weak base is to be titrated with weak acid, the indicator used is:
a. methyl orange b. phenolpthalein c. no indicator is suggested
27. indicator in redox titration using KMnO4
a. starch b. methyl red c. phenolpthalein
28. most suitable indicator to use in the titration of organic acids
a. phenolpthalein b. methyl red c. All
29. the equilibrium constant for the reaction of metal ion with a ligand is called:
a. a formation constant b. solubility constant c. NOTA
30. a molecule w/c provides groups of attachment to metal ios.
a.chelate b. ligand c. both a & b
31. in the standardization of iodine solution, why is there need to boil the solution of arsenic trioxide ?:
a. it makes the solution stable b. it increases the solubility
32. color of the complex resulting from reaction with ferrous phenanthroline:
a. red b. blue C. PINK D. VIOLET
33. types of chemical reaction used in the volumetric analysis:
a. redox b. neutralization c. diazotization d. aota
34. if starch TS is used as an indicator, the end point is / are:
a. appearance of intense blue color c. both of the choices
b. disappearance of intense blue color d. NOTA
35. a substance w/c gains electrons in a redox reaction:
a. oxidizing agent b. reducing agent c. NOTA d. AOTA
36. indicators used in non aqueous titrimetry:
I. nile blue II. Crystal violet III. Malachite green IV phenolphthalein
a. I only b.I & II only c. I, II, III only d. all
37. standard solutions are also known as :
a. test solutions b. saturated solutions c. volumetric sol
38.std. sol in non-aqueous titrimetric analysis-acidimetry
a. perchloric acid b. hydrogen bromide c. both d. none
39. w/c of the following is added to maintain the pH of sodium thiosulfate
in optimum range for the stability of the solution?:
a. sodium bicarbonate b. sodium carbonate c. chloroform
40. a ligand that binds to a metal ion through only one atom.
a. monodentate b. bidentate c. tridentate d. tetradentate
41. other name of systemic error:
a. random b. determinate c. indeterminate d. both a & b
42. the term dried to constant weight means that two consecutive weighing do not differ by more than:
a. 0.0002 g. b. 0.2 g c. 0.5 mg/g d. aota
43. primary std in the standardization of sodium methoxide:
a. benzoic acid b. sodium bicarbonate c. sodium carbonate
44. describes how close a measured value is to the true value:
a. precision b. accuracy c. range d. std deviation
45. reasons why residual titration are performed:
a. poor solubility b.rx'n proceeds slowly
c. sample doesn’t give sharp end point d. aota
46. use to prevent one element from interfering in the analysis of another element:
a. masking agent b. demasking agent c. both a & b
47. std. sol. In precipitation method of analysis:
a. disodium edetate b. silver nitrate & NH4SCN c. perchloric acid
48. solutions containing all the reagents & solvents used in the analysis, but no deliberately added analyte.
a. blank sol b. sol with sx c. test sol d. std. solution
49. the end point in using number ferric ammonium sulfate is :
a. white precipitate b. red brown color c. pink color
50. limit of moisture in non-aqueous titrimetric analysis is less than:
a. 0.5 % b. 0.05 % c. 0.2 % d. 0.02 %
51. Animal used in the assay of oxytocin injection.
52. animal used in Bio assay for parathyroid injection based on measuring the increase in serum calcium.
53. animal in toxicity test for plastic infusion tubes
54. pyrogen test animal
55. animal used in safety & toxicity test
56. Standard Operating Procedure (SOP):
a.concerned with record keeping c. step by step method
b.done to facilitate recall d. all of these correct
57.A Critical defect that would stop the packaging line operations:
a. wrong labels b. inverted labels c. smeared labels
58. Pyrogen test in vitro:
a. colorimeter b. LAL method c. fluorimeter
59. the sampling & examination of all raw materials received by the factory
is a function of the :
a.documentation section c. biological testing lab.
b.materials inspection d. analytical laboratory
60. a firm’s removal or correction of a distributed product w/c involves no
violation:
a. drug recall c. market withdrawal
b. stock recovery d. one of the above
61.a defect that may affect the function of an object and therefore, may
render the product useless
a. major b. minor c. critical d. ocular defect
62. the dye used in the leaker test:
a. methylene blue b. thymol blue c. phenolpthalein d. NOTA
63. the QC manager is not in charged of this section:
a. analytical lab c. specs & analytical dev’t
b. biological testing d. R& D section
64. determine the shelf life of a product
a.sampling inspection program c. validation program
b.stability testing program d. all
65. the test for content uniformity is required for :
a.film-coated tablets c. solutions for inhalations
b.suspensions d. liquid-filled soft caps
66. uv-vis spectro is usually used for:
a.identification of organic compounds
b.identification of inorganic compounds
c.concentration or quantitative determination
67.absorbances is directly proportional to concentration to conc &
pathlengths:
a. bouger-beer’s law b.bouger-lambert c. nota
68. reciprocal of wavelength:
a. angstrom b. micrometer c. nota
69.the visible region of the spectra has a wavelength of:
a. 100-600 nm b. 200-380 nm c. 380-780 nm.
70. water used in preparing a parenteral products:
a.water for injection c. distilled water
b.purified water d. any of the above
71.,units of wavelength in spectro, except:
a.microns b.angstrom c. millimeter d. nanometer
72.the IR region of the spectro used to identify a substance uses a wavelength of:
a.100-600 nm. b. 200-380 nm. c.380-780 nm d. 3-15 um.
73..the degree of possession of those characteristics designed & manufactured into w/c contributes to the performance of an intended functions when the product is used as directed.
74. one or more units drawn at random from a lot or batch:
a. sample b. process control c. both d. nota
75. concept of quality includes:
a. fitness for use b. conformance to spec. c. both a & b
76. any non-conformance of the unit of product with specified requirements:
a. accepted b. defect c. rejected d. nota
77. one or more units drawn at random from a lot or batch:
a. sample b. process control c. both
78.period in w/c the product remains acceptable for use:
a. stability b. shelf-life c. accelerated stability
79. potency of a 100 mg tab at expiry date:
a. 95 mg b. 90 mg c. 85 mg d. nota
80. the following are optical devices except:
a. pH meter b. spectrophotometer c. colorimeter d. nota
81.determine the shelf life of a product:
a. stability testing b. sampling inspection c. validation program
82. an analyst who determines the strength, potency, and percentage purity of a drug or
phar’l product is :
a. phar’l assaying b. special method c. identification test
83. to determine the total ash, the sample is incinerated at a temp of 675+-25 deg centigrade. this temp is represented by:
a. bright red heat b. dull red heat c. very dull red heat
84. analysis where separation of the constituent from the sample is done than weighing the products is:
a. volumetric b. gravimetric c. special
85. a sterile parenteral solution is also non pyrogenic
a. all the time b. most of the time c. sometime d. NOTA
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