Monday, October 5, 2009

QUALITY CONTROL 2 WITH INSTRUMENTATION SAMPLE QUESTIONS FOR FINAL GRADING PERIOD

Identify the following:
1. this type of refractometer is extensively used in pharmaceutical analysis because of its simplicity and ease of manipulation.
2. two of the basic principles upon which chromatographic separations is dependent on., aside form the ion-exchange & molecular exclusion.
3. a type of chromatography w/c uses inert gas, as the mobile phase
4. a solid adsorbent used as filter paper
5. a process in w/c a sol of a mixture contains an inert materials , drug principles
and impurities is separated into its component.
6.method in chromatography with greater speed, precision, accuracy & ease of
manipulation.
7. thin layer chromatography
8. the adsorbent used in thin Layer chromatography
9. two of the basic principles upon which chromatographic separations is dependent on.
10. commonly used to develop chromatograms
11. fingerpoint region in IR spectrometry
12..the heart & soul of HPLC & GC
13. # of tablets conducted in content uniformity test
14. assures that the oldest stock is used ist policy
15. absorbance is directly proportional to conc & pathlength
16. linear distance from any point of 1 wave to the corresponding point on the adjacent wave
17. refer to water suitable for drinking
18. measures the index of refraction of a chemical substance
19. .the dye used in leakers test
20. a molecule w/c provides groups of attachment to metal ions.
TRUE OR FALSE:
1 the statement method I of WCD in USP 27 is the ATDM. IS CORRECT
2 iodometry is an indirect analysis of oxidizing agent
3. when a reducing analyte is titrated directly with iodine, the method used is called IODIMETRY.
4. to keep samples moisture free, the appropriate apparatus to use is incubator.
5. the use of NaHCO3 in the standardization of iodine solution is: to inc the solubility
6. when a weak base is to be titrated with weak acid, the indicator used is methyl orange
7. indicator in redox titration using KMnO4 is starch.
8. most suitable indicator to use in the titration of organic acids is methyl red.
9. the equilibrium constant for the reaction of metal ion with a ligand is called solubility constant
10. a molecule w/c provides groups of attachment to metal ios is chelate
11. in the standardization of iodine solution, there is a need to boil the solution of arsenic trioxide to inc the solubility
12. the color of the complex resulting from reaction with ferrous phenanthroline is pink.
13. types of chemical reaction used in the volumetric analysis is diazotozation
14. if starch TS is used as an indicator, the end point is the appearance of intense blue color:
15. a substance w/c gains electrons in a redox reactiona is an oxidizing agent .
16. indicators used in non aqueous titrimetry is phenolphthalein.
17. standard solutions are also known as test solutions.
18.std. sol in non-aqueous titrimetric analysis-acidimetry perchloric acid
19. sodium carbonate is added to maintain the pH of sodium thiosulfate
in optimum range for the stability of the solution?:
20. a ligand that binds to a metal ion through only one atom.
a. monodentate b. bidentate c. tridentate d. tetradentate
Multiple Choice/Identification
1. methyl orange in base medium is colored:
a. colorless b. yellow c. pink d. green
2. titer is an expression of concentration in terms of :
a. g. per liter b. g or mg of solute per mL
3. analysis where separation of the constituents from the sample is done
and then weighing the product is:
a. volumetric b. gravimetric c. special
4. to keep samples moisture- free the apparatus used is:
a. dessicator b. incubator c. furnace
5. the type of ash where sulfuric acid is used to whiten the ash is:
a. acid insoluble ash b. sulfated ash c. loss on ignition
6. the oil from peppermint spirit can be determined by using:
a. cassia flask b. bobcock bottle c. pycnometer
7. the unsaponifiable matter present in animal fats is:
a. cholesterol b. phytosterol c. cellulose
8. the crude fiber of a drug usually consists of:
a. cellulose b. cholesterol c. phytosterol
9. hexane is the best solvent in extracting:
a. resins b. fats c. volatile oil
10. the instrument used to measure the optical activity of the sample is:
a. refractometer b. polarimeter c. spectrometer
11. Process of measuring the actual quantity of mass, volume, force, etc. that correspond to an indicated quantity on the scale of an instrument.
a. weighing b. calibration c. nota d. both a & b
12. residue on ignition is also called:
a. loss on ignition b.sulfated ash c. acid-insoluble ash
13. method I for determining alcohol-soluble extractives is also known as:
a. hot extraction b. cold extraction c. hot compressed d. cold
14. the type of alkaloidal assay where the total alkaloid is determined
a.proximate b.ultimate c. specific d. extraction
15. w/c of the following statement/s is correct?
I. in azeotropic method of water analysis, toluene is used as solvent
II. in AMOWA, toluene & xylene are used as solvents
III. in AMOWA, toluene, xylene, and water are used as solvents
a. I only b. I, II only c. I, II, & III d. NOTA
16. the 0.1N iodine solution is standardized using:
a. pot,. Permanganate b. arsenic trioxide c.sod. carbonate
17. the active fraction of starch w/c react with iodine to form an intense blue color is:
a. amylose b. amylopectin c. glucose d. sucrose
18. also known as eosin y.:
a. tetrabromofluorescein b. xylenol orange c.dichlorofluorescein
19. what is the use of HgI2 in the preparation of starch TS?
a. to increase the solubility of starch b. act as a preservative
20. primary standard used to standardize Karl Fischer reagent is :
a. sodium tartrate b. pot. Hydrogen phthalate
21. w/c of the following statement/s is /are correct:
I. method I of WCD in USP 27 is the ATDM.
II method II of WCD in USP 27 is the titrimetric method.
III method III of WCD in USP 27 is the gravimetric Method
IV .method IV of WCD in USP 27 is the Karl Fischer Method
a. I only b. II only c. III only d. IV only
22. iodometry is an indirect analysis of:
a. oxidizing agent b. reducing agent c. acid d. base
23. when a reducing analyte is titrated directly with iodine, the method used is called:
a. iodometry b. iodimetry c. cerimetry d. permangonometry
24. to keep samples moisture free, the appropriate apparatus to use is:
a. separatory funnel b. dessicator c. incubator
25. the use of sodium bicarbonate in the standardization of iodine solution is:
a. to increase the solubility b. as buffer c. as preservative
26. when a weak base is to be titrated with weak acid, the indicator used is:
a. methyl orange b. phenolpthalein c. no indicator is suggested
27. indicator in redox titration using KMnO4
a. starch b. methyl red c. phenolpthalein
28. most suitable indicator to use in the titration of organic acids
a. phenolpthalein b. methyl red c. All
29. the equilibrium constant for the reaction of metal ion with a ligand is called:
a. a formation constant b. solubility constant c. NOTA
30. a molecule w/c provides groups of attachment to metal ios.
a.chelate b. ligand c. both a & b
31. in the standardization of iodine solution, why is there need to boil the solution of arsenic trioxide ?:
a. it makes the solution stable b. it increases the solubility
32. color of the complex resulting from reaction with ferrous phenanthroline:
a. red b. blue C. PINK D. VIOLET
33. types of chemical reaction used in the volumetric analysis:
a. redox b. neutralization c. diazotization d. aota
34. if starch TS is used as an indicator, the end point is / are:
a. appearance of intense blue color c. both of the choices
b. disappearance of intense blue color d. NOTA
35. a substance w/c gains electrons in a redox reaction:
a. oxidizing agent b. reducing agent c. NOTA d. AOTA
36. indicators used in non aqueous titrimetry:
I. nile blue II. Crystal violet III. Malachite green IV phenolphthalein
a. I only b.I & II only c. I, II, III only d. all
37. standard solutions are also known as :
a. test solutions b. saturated solutions c. volumetric sol
38.std. sol in non-aqueous titrimetric analysis-acidimetry
a. perchloric acid b. hydrogen bromide c. both d. none
39. w/c of the following is added to maintain the pH of sodium thiosulfate
in optimum range for the stability of the solution?:
a. sodium bicarbonate b. sodium carbonate c. chloroform
40. a ligand that binds to a metal ion through only one atom.
a. monodentate b. bidentate c. tridentate d. tetradentate
41. other name of systemic error:
a. random b. determinate c. indeterminate d. both a & b
42. the term dried to constant weight means that two consecutive weighing do not differ by more than:
a. 0.0002 g. b. 0.2 g c. 0.5 mg/g d. aota
43. primary std in the standardization of sodium methoxide:
a. benzoic acid b. sodium bicarbonate c. sodium carbonate
44. describes how close a measured value is to the true value:
a. precision b. accuracy c. range d. std deviation
45. reasons why residual titration are performed:
a. poor solubility b.rx'n proceeds slowly
c. sample doesn’t give sharp end point d. aota
46. use to prevent one element from interfering in the analysis of another element:
a. masking agent b. demasking agent c. both a & b
47. std. sol. In precipitation method of analysis:
a. disodium edetate b. silver nitrate & NH4SCN c. perchloric acid
48. solutions containing all the reagents & solvents used in the analysis, but no deliberately added analyte.
a. blank sol b. sol with sx c. test sol d. std. solution
49. the end point in using number ferric ammonium sulfate is :
a. white precipitate b. red brown color c. pink color
50. limit of moisture in non-aqueous titrimetric analysis is less than:
a. 0.5 % b. 0.05 % c. 0.2 % d. 0.02 %
51. Animal used in the assay of oxytocin injection.
52. animal used in Bio assay for parathyroid injection based on measuring the increase in serum calcium.
53. animal in toxicity test for plastic infusion tubes
54. pyrogen test animal
55. animal used in safety & toxicity test
56. Standard Operating Procedure (SOP):
a.concerned with record keeping c. step by step method
b.done to facilitate recall d. all of these correct
57.A Critical defect that would stop the packaging line operations:
a. wrong labels b. inverted labels c. smeared labels
58. Pyrogen test in vitro:
a. colorimeter b. LAL method c. fluorimeter
59. the sampling & examination of all raw materials received by the factory
is a function of the :
a.documentation section c. biological testing lab.
b.materials inspection d. analytical laboratory
60. a firm’s removal or correction of a distributed product w/c involves no
violation:
a. drug recall c. market withdrawal
b. stock recovery d. one of the above
61.a defect that may affect the function of an object and therefore, may
render the product useless
a. major b. minor c. critical d. ocular defect
62. the dye used in the leaker test:
a. methylene blue b. thymol blue c. phenolpthalein d. NOTA
63. the QC manager is not in charged of this section:
a. analytical lab c. specs & analytical dev’t
b. biological testing d. R& D section
64. determine the shelf life of a product
a.sampling inspection program c. validation program
b.stability testing program d. all
65. the test for content uniformity is required for :
a.film-coated tablets c. solutions for inhalations
b.suspensions d. liquid-filled soft caps
66. uv-vis spectro is usually used for:
a.identification of organic compounds
b.identification of inorganic compounds
c.concentration or quantitative determination
67.absorbances is directly proportional to concentration to conc &
pathlengths:
a. bouger-beer’s law b.bouger-lambert c. nota
68. reciprocal of wavelength:
a. angstrom b. micrometer c. nota
69.the visible region of the spectra has a wavelength of:
a. 100-600 nm b. 200-380 nm c. 380-780 nm.
70. water used in preparing a parenteral products:
a.water for injection c. distilled water
b.purified water d. any of the above
71.,units of wavelength in spectro, except:
a.microns b.angstrom c. millimeter d. nanometer
72.the IR region of the spectro used to identify a substance uses a wavelength of:
a.100-600 nm. b. 200-380 nm. c.380-780 nm d. 3-15 um.
73..the degree of possession of those characteristics designed & manufactured into w/c contributes to the performance of an intended functions when the product is used as directed.
74. one or more units drawn at random from a lot or batch:
a. sample b. process control c. both d. nota
75. concept of quality includes:
a. fitness for use b. conformance to spec. c. both a & b
76. any non-conformance of the unit of product with specified requirements:
a. accepted b. defect c. rejected d. nota
77. one or more units drawn at random from a lot or batch:
a. sample b. process control c. both
78.period in w/c the product remains acceptable for use:
a. stability b. shelf-life c. accelerated stability
79. potency of a 100 mg tab at expiry date:
a. 95 mg b. 90 mg c. 85 mg d. nota
80. the following are optical devices except:
a. pH meter b. spectrophotometer c. colorimeter d. nota
81.determine the shelf life of a product:
a. stability testing b. sampling inspection c. validation program
82. an analyst who determines the strength, potency, and percentage purity of a drug or
phar’l product is :
a. phar’l assaying b. special method c. identification test
83. to determine the total ash, the sample is incinerated at a temp of 675+-25 deg centigrade. this temp is represented by:
a. bright red heat b. dull red heat c. very dull red heat
84. analysis where separation of the constituent from the sample is done than weighing the products is:
a. volumetric b. gravimetric c. special
85. a sterile parenteral solution is also non pyrogenic
a. all the time b. most of the time c. sometime d. NOTA

PHARMACEUTICAL CHEMISTRY I SAMPLE QUESTIONS

Pharmaceutical Chemistry I
Sample Questions for final grading period

TRUE OR FALSE
1. AN ELEMENT THAT IS USED TO TREAT SCABIES IS SULFUR.
2. SODIUM METAL IS A COMPONENT OF HEMOGLOBIN
3. BECAUSE OF ITS LIGHTNESS, NEON IS USED TOGETHER WITH OXYGEN AS ARITIFICIAL AIR
4. % CONCENTRATION OF NSS IS 9 %
5. CHLORIDE IS THE SALT OF HCL
6. ISOTONIC IS A SOLUTION IN W/C OSMOTIC PRESSURE IS THE SAME AS THE BLOOD
7. AQUA FORTIS IS SULFURIC ACID
8. ATOMS & MOLECULES ARE THE BUILDING UNITS OF MATTER
9. CUPRIC ION IN SOLUTION IS COLORED BLUE
10. OXYGEN IS THE MOST ABUNDANT ELEMENT
11. HYDROGEN SULFIDE TS MUST BE FRESHLY PREPARED
12. ZnSO4 IS THE TITRANT USED IN DIRECT COMPLEXITY ANALYSIS
13. ZnS IS THE ONLY WHITE SULFIDE
14. Mg++ IS THE ANION THAT PRODUCES A SALMON COLORED PPT W/ FeCl3 TS
15. SNOWFALL IS A VISIBLE MASS OF FOG SUSPENDED AT THE HEIGHT OF AIR
16. WHEN WATER IS CHANGE TO HYDROGEN AND OXYGEN MOLECULE BY ELECTROLYSIS, THE CHANGE IS DESCRIBED AS CHEMICAL CHANGE
17. SALITRE OR SALT PETER WHICH IS AMEAT PRESERVBATIVE IS THE SYNONYM FOR KNO3.
18. THE SECOND RADIOACTIVE ELEMENT DISCOVERED BY MDM MARIE CURIE AND USED MEDICINALLY AS A SOURCE FOR RADIATION IN CANCER THERAPY IS RADIUM
19. THE ONLY SYNTHETIC AND RADIOACTIVE HALOGEN IS ASTATINE.
20. BORDEAUX MIXTURE, AN ALGACIDE-FUNGICIDE USED IN SWIMMING POOLS CONTAINS COPPER
21. LUNAR CAUSTIC OR LAPIZ ENFERNALIS IS CHEMICALLY KNOWN AS SILVER NITRATE
22. TAWAS IS POTASSIUM ALUM
23. QUICKSILVER IS MERCURY
24. GREEN VITRIOL IS FESO4
25. BLUE VITRIOL IS COPPER SULFATE
26. WHITE VITRIOL IS ZnSO4
27. OIL OF VITRIOL IS SULFURIC ACID
28. MURIATIC ACID IS HYDROCHLORIC ACID
29. PURIFIED SILICEOUS IS SILICON DIOXIDE
30. DRY ICE IS SOLID CARBON DIOXIDE
31. BAKING SODA IS SODIUM BICARBONATE
32. ST. ELMO’S FIRE IS PHOSPHORUS
33. KING OF ALL METALS IS GOLD
34. LIGHTEST OF ALL METALS IS LITHIUM
35. SEA SALT PRODUCERS ARE HALOGENS
36. MOST ABUNDANT EXTRACELLULAR CATION IS SODIUM
37. ALKALI METALS W/C IS VERY REACTIVE BELONG TO GROUP 1A
38. TOXICITY WITH SILVER IS CALLED ARGYRIA
39. MOST MALLEABLE & BEST CONDUCTOR OF ELECTRICITY IS GOLD
40. BRONZE IS A MIXTURE OF COPPER & TIN
41. BRASS IS A MIXTURE OF COPPER & ZINC
42. KNOWN AS THE COINAGE METAL IS THE GROUP 1B
43. TOXICITY OF METAL CAN CAUSE WILSON’S DISEASE BY COPPER
44. THE ONLY METAL USED IN WATER PURIFICATION
45. AGNO3 IS USED IN INDELIBLE INK
46. USED IN BACTERIAL FIXING OF ATMOSPHERIC NITROGEN IS CHROMIUM
47. THE SOLUBLE SILVER SALTS ARE TOXIC
48. OSMIC ACID IS USED IN STAINING OF MICROSCOPIC SPECIMENS
49. BEST ANTIDOTE FOR ALKALOIDAL POISONING
50. MOLYBDENUM IS USED AS GLUCOSE TOILERANCE FACTOR
51. IST ELEMENT PRODUCED ARTIFICIALLY IS TECHNETIUM
52. KNOWN AS THE MESSENGE OF GOD IS MERCURY
53. TH ONLY ELEMENT IN GROUP V-B W/ IS EMPLOYED THERAPEUTICALLY IN SURGICAL REPAIR OF BONES IS TANTALUM
54. GOLD CAN BE DISSOLVE BY A SOLUTION OF ROYAL WATER( AGUA REGIA)
55. RHENIUM IS A VERY RARE ELEMENT W/C FINDS FEW TECHNICAL APPLICATIONS

Multiple Choice/ Identification

___1. the property of chemicals to destroy one form of life without harming another
a. selective toxicity b. stereoisomerism c. bioselectivity
___2. an agent that prevents infection by the destruction of pathogenic microorganisms when applied to inanimate object.
a. antiseptic b. disinfectant c. antibiotic
___3. ethanol that has been rendered unfit for use in intoxicating beverages by the addition
of other substances.
a. denatured alcohol b. woodalcohol c. isopropyl alcohol
___4. a 2% solution of iodine in 50% alcohol with sodium iodide.
a. iodine solution b. iodine tincture c. lugol’s solution
___5. a preparation of 5% iodine in water with potassium iodide.
a. iodine solution b. lugols solution c. iodine tincture
___6. generally accepted other names of alcohol USP.
a. ethanol b. wood alcohol c. wine spirit d. AOTA
___7. a preparation of 2% iodine in water with sodium iodide
a. iodine solution b. iodine tincture c. lugol’s solution
___8. a propylamine derivative:
a. diphenhydramine b. brompheniramine c. doxylamine
___9. the major source of histamine in the body results from the decarboxylation of this amino acids.
a. tryptophan b. histidine c. tyrosine
___10.nitrates in the presence of nitron reagent gives
a. white ppt b. blue ppt c. NVR
___11.this ion when warmed w/ conc. H2SO4 and metallic Cu, evolced brown gas; (+) result
with brown ring test, and no visible reaction w/ diluted H2SO4
a. nitrite b. nitrate c. acetate
___12. magnesium ion is detected using this dye stuff in alkaline sol forming a blue lake
a. aluminon reagent b. amaranth c. p-NBAR
___13. zinc white is :
a. zinc oxide b. zinc sulfide c. zinc chloride
___14. flame tests are observed under:
a. non-luminous flame b. luminous c, both d. none
___15. form precipitates w/ dilute HCl
a. insoluble chloride group b. soluble group c. acid insoluble group
16. Produces choc. Brown ppt. soluble in HNO3 acid when mixed with AgNO3 TS.
17. produces an olive green solution with NaOH.
18. produces red lake with aluminon reagent
19. produces a white ppt turning yellow when added with HCl.
20. produces a yellow ppt with potassium nitrite and acetic acid
21. produces a scarlet soluble ion excess with KI
22. produces a white curdy ppt soluble inNH3, insol in nitric acid.
23. uses silver mirror test for identification
24. uses also silver mirror test for identification
25. produces violet color with ferric chloride.
26. Most abundant of all elements in the earth’s crust.
27. 2nd most abundant element.
28. a measure of the acidity of a solution.
29. generic term referring to vitreous materials.
30. weight of a solute in a given quantity of water.

MBTM 09