Clinical Toxi. Outline Pre-Mid Exam. 2010-11

Clinical Toxicology Outline
Pre-Mid Examination
2nd Semester 2010-2011


Test I: instruction will be given during exam.day
1. The choice of the professional poisoner:
2. a specialized field of toxicology that designates an area of professional, emphasis within the realm of medical science:
3. the major route by which toxic agents gain access to the body are through the following except:
4. a poison which increases suddenly in its intensity of action after slow or gradual addition of it is called:
5. evidences obtained from an examination of the tissues and organs of the dead.
6. evidences obtained after detection of suspected substance via analysis of samples of body fluids collected
7. evidences from events., facts but can not be considered as a strong evidence.
8. evidences obtained by administering the suspected substance to living animals.
9. a poison which has a prompt, marked disturbance of function or death within short period of time:
10. this type of patient related genetic defect may lead to toxicity:
11. a poisoning effect that possesses both local and remote effects
12. the evidences to be saved in non-fatal poisoning are the following: except:

13. when reporting cases of poisoning like eating in a public restaurant, the cases should be reported to the:
14.most accidental poisoning in children is caused by:
15.???


Test II:
1. toxicology has been derived from the greek word?
2. an organ thru which nearly all the poisons are eliminated is the ?
3. it was ???? who ist refuse to discuss about the nature of the poisons.
4. all?????have their properties to fix themselves to certain tissues of the body.
5. washing is often advisable even after free vomiting as some adhere to stomach walls.
6. there is no ?????distinctive chemical test for certain poisons.
7. symptoms of food poisoning are usually those of a ????? intestinal irritation.
8. poisons affect the ???& cause death by sudden shock and collapse.
9. gaseous poisons are not deposited but promptly removed by way of the ????
10.almost every poison has been known to produce ???? effect, but the only true convulsive poisons are the alkaloids of the ?????class.
Test III- Matching Type Manifestation shown as indicated by the poison: Letter/s only.
A. BLOOD CHANGES
1. dark red blood a. aniline
2. cherry red blood b. heparin/coumarin/ benzene
3. chocolate blood c. CO/ cyanide
4. blood coagulabilioty decreases d. nicotine
B. SKIN DISCOLORATION:
1. palebonds on fingernails a. boric acid
2. yellow b. Ag salts
3. Ash gray c. arsenic
4. brown black d.physostigmine
5. bleaching white e. Br
6. deep brown f. HNO3
7. blue g. H2SO4 acid
8. bluish gray h. phenol
9. boiled lobster appearance i. cyanotics
C. ODOR OF BREATH/ DISCOLORATION OF GUMS
1. black gum line a. acetone
2. stale tobacco b. nicotine
3. mouse urine c. cyanide
4. shoe polish d. nitrobenzene
5. fruity odor e. Hg
6. garlic odor f. Bi
7. blue gum line g. coniine
8. sweet penetrating odor h. ethanol
9. bitter almonds i. malathion
D. POISONS DETECTED FROM CHEMICAL TESTS
1. KI a. heavy metals
2. modified duquenois b. mercury
3. marquis c. aniline
4. bromine water d. halogens
5. AAS e. marijuana
6. brown ring f. opium
7. beilstein g. bismuth
8. nylander h. nitrates

E. VISUAL/ RESPIRATORY DISTURBANCES
1. irritation a. marijuana
2. blurred vision b. methyl alcohol
3. blood shot eyes c. anticholinergic
4. violent sneezing d. SO2
5. partial/ total blindness e. veratrine
F. OTHER CHANGES
1. luminous vomitus/alopecia a. salicylates
2. blue green vomitus b. anticholinergic
3. ground coffee vomitus c. arsenic
4. blister formation d. copper
5. bloody sputum e. H2SO4
6. tinnitus f. cadmium
7. lock jaw g. barium
8. loss of voice h. cantharidin
9. bleeding gums i. strychnine
10. xerostomia j. mercury
Goodluck!!!!Happy New Year!

Manufacturing lec/lab Pre-Mid Exam Outline

Pharmaceutical Manufacturing Outline
Pre-mid Examination  2^nd sem. Year 2010-2011

Instruction will be given on the day of the exam.(either identification/multiple choice)

Test I:??

--------- 1. High resistant borosilicate glass is also referred to as:

______2. General purpose soda-lime glass

______3. treated soda lime glass with sulfur dioxide and is suitable for buffered

parenteral solutions, and has a pH of below 7, & is not reactive with glass

______4.  regular soda lime glass

5. suppositories are made by:

6. rule of thumb is the principle applied for testing:

7. anteroom, which separates the sterile areas from non-sterile areas;

8. CGMP means:

9. an equipment associated with the maintenance of dust –free areas; 

10. a common lubricant added to tablet granulations:

11. this statement is true of the FIFO policy:

            a. prevents contaminations and mix- ups

            b. assures that the oldest stock of material is used first

            c. contains information regarding the activity of the component.

            d. AOTA

12. diluent of choice for chewable tablets:

13. freeze-drying is also known as:

14. most biologicals are store at this temperature:

15. a class of raw materials, which are to be subjected to tests and assays by

      the  Quality Control Department, and are not yet to be used in the production of     

      pharmaceuticals:

16. refers to the addition of an active in an unstable pharmaceutical preparations, to   

      compensate for the loss during  manufacture:

17. the following are the effects of product recalls to a drug- manufacturing firm:

18. a special technique for poorly- soluble drugs, in which it is improved by the

      addition of a water- miscible solvent, in which the drug will have increased water

      solubility:

19.  a standard document, which give instructions to the production department to

       produce a pharmaceutical product for distribution/ sale in the market ;

20. examples of primary packaging components;

21. this raw material can be used as a tablet diluent, disintegrant and binder:

22. strip- sealed tablets are evaluated for:

23. a system for ensuring that products are consistently produced and controlled according to quality standards. It is designed to minimize the risks or errors involved in any pharmaceutical production, which cannot be eliminated through the final  testing of the product:

24. an instrument used to check the tightness of the cap/closure:

25. a tablet processing problem characterized by the separation of the tablet into several distinct layers;

26. uneven distribution of color in tablet coating is due to :

27. a batch or any portion of a batch of drug produced by a continuous process is:

28. sealing of ampule is done by:

29. classified as sterile product although not injected into the body:

30. fever producing substances arising from microbial contamination are:

          

Test II: Draw the Organiztional Chart of a typical Manufacturing firm.(10 pts.)

Test II:Sketch the chart representing different division. Sections of Manuf’g area(5pts)

Test III: draw the chart under the raw materials and differentiate the color being used. (10 pts.)

Test III: Give the three classification of bottle defects and give five (5) examples of each.(15 pts.

                                                GOODLUCK!!!!