clin toxi syllabus

A Syllabus for the Proposed Pharmacy Curriculum
Course Title : Clinical Toxicology
Course Number :
Credit Units : 3 units (2 units lecture, 1 unit laboratory), 4th year 1st sem
Course Description : The fundamentals of clinical toxicology including a study of the general classes of toxic agents, mechanism of toxicity, target organ toxicity, management, and their detection.
Prerequisite(s) : Pharmacology 1 , Pharmacology 2 (corequisite)
General Objectives : At the end of the course,
1. The students should acquire basic knowledge in the origin and type of exposure, stages in the induction of toxicity and evidences in poisoning.
2. The students should be able to identify the commonly encountered deleterious chemicals and drugs to man and his environment.
3. To manifest the pharmacist responsibility in the risk assessment and management of poisoning
Course Outline :
Specific Objectives Topics Time Allotted Teaching Strategies Evaluation Tool

At the end of the course, the student must be able to:
1. Discuss and explain important concepts in toxicology (toxicodynamics, toxicokinetics, teratology, carcinogenesis, occupational toxicology, environmental toxicology and organ toxicology)
2. Identify important information regarding the specific poisons and toxic agents like the mechanism of toxic action, toxic effects and symptomatology, management and resources.

A. General Concepts
1. Introduction
a. Definition of toxicology and its importance in the practice of pharmacy
b. Definition of terms
c. Areas in Toxicoloy
2. Toxicodynamics
3. Toxicokinetics
a. Dose-Response Relationship (LD50, LOAEL & NOAEL)


Lectures with Audio-visual Aids (Powerpoint)
Group dynamics
Pre and Post Quizzes
Oral Exams and/or graded recitations on assigned topics
Performance in the Written Examinations

Specific Objectives Topics Time Allotted Teaching Strategies Evaluation Tool
3. Assess and solve basic clinical problems in relation to toxicology.
4. Identify chemicals that commonly cause poisoning through laboratory tests.
5. Demonstrate the proper techniques and observe precautions in handling and identifying poisons or potential poisons.
6. Properly handle animals (e.g. guinea pig, mouse) for chemical analysis of poisons in the laboratory.
B. Clinical Toxicology
1. Principles of Clinical Toxicology
2. General Management of a Suspected Poisoned Patient
a. Emergency stabilization
b. Clinical evaluation
c. Elimination of the poison
d. Excretion of absorbed substances
e. Antidotes
f. Supportive therapy
g. Disposition

3. Management of Specific Poisons
a. Therapeutic agents
i. Analgesics
ii. Anti-infective drugs
iii. Cardiovascular drugs
1. Antihypertensive
2. Antiarrythmics
3. Lipid-lowering drugs
iv. CNS drugs
1. Anticonvulsants
v. Psychotropic agents
1. Antidepressants
2. MAOI
3. Neuroleptic agents
4. Sedative-hypnotic drugs
vi. Respiratory drugs
vii. GI drugs
viii. Endocrine drugs
b. Drugs of Abuse
i. Opiates
ii. Amphetamine (diet pills, cough syrups)
iii. Marijuana and cannabinoids
iv. Hallucinogenic drugs
Lectures with Audio-visual Aids (Powerpoint)
Group dynamics
Pre and Post Quizzes
Oral Exams and/or graded recitations on assigned topics
Performance in the Written Examinations

Specific Objectives Topics Time Allotted Teaching Strategies Evaluation Tool
c. Household Poisons
d. Pesticides
e. Heavy metals
f. Inhalatory Poisons
g. Environmental Poisons

References :

Prepared by :Marybelen T. Mogol, RPh.,MSPharm