A Course Syllabus in Pharmaceutical Chemistry 1
Course Title : Chemistry and Pharmacy of Inorganic Medicinals with Qualitative Chemistry
Course Number : Pharmaceutical Chemistry 1
Credit Units : 5 units credit (3 hours lecture, 6 hours lab / week) Third Year, First Semester
Course Description : The course covers the chemistry and pharmacy of inorganic medicinals, with emphasis on those officials in the USP and NF, their preparations, properties, tests and uses. It includes the concepts and chemical reactions related to qualitative analysis of inorganic compounds.
Prerequisite(s) : Chemistry 1 (General & Inorganic Chemistry) Pharmacy 1 (Introduction to Pharmacy)
General Objectives : At the end of the course, the students should be able to:
1. Apply the knowledge, skills, principles of inorganic chemistry to medicinal and pharmaceutical chemistry.
2. Discuss the official inorganic substances used as therapeutic and diagnostic agents.
3. Manifest an appreciation of the pharmacist’s social and professional responsibilities in maintaining or restoring the health of men and animals.4. Understand the high moral and ethical standards of the pharmacy profession.
Course Outline :
Specific Objectives Topics Time Allotted Teaching Strategies Evaluation Tool
The students are expected to:
1. Determine the rate of reaction in terms of concentration of reactants vs time.
2. Express rate law in terms of rate constants and concentration of reactants.
3. Identify the factors that affect the rate of reactions.
4. Differentiate reversible and irreversible reactions.
5. Formulate equilibrium expressions as applied to homogeneous and heterogeneous systems
6. Solve problems involving pH, pOH and buffer solutions.
I. Kinetics and Chemical Equilibrium
1. Reaction Rates and Rate Laws
2. Collision Theory and Reaction Rates
3. Factors that Control Reaction Rate
4. Reversible Reaction and Chemical Equilibrium
5. Chemical Equilibrium Constants (Ke, Ksp, Ki)
6. Calculations involving Equilibrium Constants – pH, pOH and buffer solutions 8 hrs Class Discussion,Problem SetsBoard ,Work Recitation Report Use of Overhead Projector/Multimedia Quizzes Graded recitation
Unit Examination,Periodical Examination
Specific Objectives Topics Time Allotted Teaching Strategies Evaluation Tool
The students are expected to:
1. Characterize elements of different groups in the periodic table.
2. Discuss and illustrate important chemical reactions.
3. Identify ions and compounds.
The students are expected to:
1. Identify the different pharmaceutical aids and necessities
2. Describe the properties of different pharmaceutical aids.
3. Discuss their importance and application to pharmaceutical preparations.
The students are expected to:
1. Differentiate the ions in intra and extra-cellular fluids.
2. Discuss the functions of these ions in maintaining physiological acid-base balance.
3. Identify commercially available preparations used for electrolyte imbalance.
The students are expected to:
1. Define the ions as essential, non-essential and trace ions.
2. Explain the importance of ions in biochemical processes in the body.
The students are expected to:1
1. Define gastrointestinal agents, acidifying agents, antacids, protectives and adsorbents and saline cathartics.
2. Illustrate the mechanism of action of gastrointestinal agents.
3. Specify gastrointestinal agents as remedies for GIT disorders.
II. Group Properties of Elements (including qualitative tests for ions)
1. Representative elements
2. Transitional elements III. Pharmaceutical Aids and Necessities1. Acids and Bases2. Buffers
3. Antioxidants
4. Waters
5. Containers
IV. Major Intra and Extra-Cellular Electrolytes
1. Major physiological ions2. Physiological acid-base balance3. Electrolytes used for:a. replacement therapyb. acid-base therapyc. combination therapyV. Essential, Non-essential and Trace Ions
1. Essential Ions
2. Non-essential ions
3. Trace ions
VI. Gastrointestinal Agents
1. Acidifying agents
2. Antacids
3. Protectives and Adsorbents
4. Saline Cathartics 8 hrs5 hrs5 hrs4 hrs5 hrs Class Discussion Problem Sets Board Work Recitation Report Use of Overhead Projector/Multimedia Quizzes Graded recitation Unit Examination Periodical Examination
Specific Objectives Topics Time Allotted Teaching Strategies Evaluation Tool
The students are expected to:
1. Define topical agents, protective agents, antimicrobials, and astringents.
2. Categorize commercially available preparations according to types of topical agents.
3. The students are expected to:
1. Identify the components in dental products, anticaries agents, and dentrifices.
2. Discuss commercially available dental products used as anticaries agents and dentrifices.
The students are expected to:
1. Describe the mechanisms of action of the respiratory agents and anitdotes.
2. List commercially available preparations used as respiratory agents and antidotes.The students are expected to show the importance of excipients to pharmaceutical preparations.
The students are expected to:
1. Review concepts of radioactivity.
2. Explain how radiopharmaceuticals and contrast media are used as diagnostic / therapeutic agents.
VII. Topical Agents
1. Protective agents
2. Antimicrobials and astringents
VIII. Dental Products
1. Anticaries agents
2. Dentrifices
IX. Miscellaneous Pharmaceutical Agents
A. Respiratory Agents
1. Inhalants
2. Respiratory Stimulants
3. Expectorants/Emetics
B. Antidotes
X. Inorganic Pharmaceutical Excipients
1. Tableting Aids
2. Suspending Agents
XI. Radiopharmaceuticals and Contrast Media
1. Radiopharmaceuticals
2. Radiopharmaceutical preparations 3 hrs3 hrs3 hrs1 hr3 hrs Class DiscussionProblem SetsBoard WorkRecitation
Report
Use of Overhead Projector/Multimedia Quizzes
Graded recitationUnit Examination
Periodical Examination
Laboratory Equipment : Standard Chemistry Laboratory Equipment
References : Block, John H. et.al., Inorganic Medicinal and Pharmaceutical Chemistry, 1974, Philadelphia, Lea and Febiger, ix, 472 p.Cotton, Frank Albert, et.al., Basic Inorganic Chemistry, 3rd ed., 1995, New York, John Wiley and Sons, xii, 838 p.Discher, Clarence A., Modern Inorganic Pharmaceutical Chemistry, 2nd ed., 1985, Waveland, Prospect Heights, 631 p.Gennaro, Alfonso R. ed., Remington’s Pharmaceutical Sciences, 20th ed., 2000, Pennsylvania, Mack Publishing Company, xvi, 2000 p.Gould, Edwin S., Inorganic Reactions and Structure, 1995, New York, Henry Holt and Company, 470 p.Halperin, Jerome A., et.al., United States Pharmacopoeia and National Formulary, 24th rev and ed., 1995, Maryland, United States Pharmacopoeial Convention Inc., Lix, 2391 p.Katakis, Dimitris, Gilbert Gordon, Mechanisms of Inorganic Reactions, 1987, New York, John Wiley and Sons, xxiii, 384 p.Perry, Dale L., Sidney, L., Phillips, ed., Handbook of Inorganic Compounds, 1995, Florida, CRC Press, Inc., lv.
References : Solne, Taito O., Charles O. Wilson, Roger’s Inorganic Pharmaceutical Chemistry, 8th ed., 1967, Philadelphia, Lea and Febiger, x, 704 p.
Prepared by : Emilio Aguinaldo College
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