Pharmaceutical Manufacturing
Sample questions
Instructions will be given during the examination day. Goodluck!
MULTIPLE TYPE OF QUESTIONS:
SET A
1. used for compacting the materials in the tableting machine:
a. hopper b. feed frame c. dies d. punches
2. the component present on the largest quantity in parenterals:
a. diluents b. vehicles c. solutes d. buffers
3. weight variation is carried out in :
a. 10 tablets b. 20 tablets c. 30 tablets d. NOne
4. room temperature recognized by USP:
a. 25 degrees b. 30 degrees c. 10 degreed d.working area temp
5. uneven distribution of color on the surface of the tablets is:
a. peeling b. mottling c. capping d. lamination
6. limulus amebocyte lysate is obtained:
a. rabbits b. cats c .chicken d. white mice
7. CGMP standards & regulations are enforced by the BFAD for the purpose of:
a. assuring quality c. assuring sales
b. developing new products d. AOTA
8. large volume parenterals are employed for:
a. maintenance therapy c. prophylactic therapy
b. replacement therapy d. a & b only
9. quarantined materials delivered in the warehouse are:
a. subject to assay & test c. in-process products
b. rejectable d. releasable
10. implantation tablets are those which are administered :
a.orally b. thru the vagina c. insertion into the body tissues
11. primary packaging materials, except:
a. bottles b. capsules c. labels d. caps
12. the temperature of a cool place is:
a. not exceeding 8 degrees c. 15-30 degrees
b. 8-15 degrees d. 25 degrees
13. solid dosage formulations are more advantageous over liquid forms because of the following reasons, exceppt:
a. stability c. method of manufacture is easier
b. can be easily dispensed d. not prone to bacteria
14. aside from fluidity, powders for compression must possess:
a. flowability b. adhesiveness c.compressibility
15. separation of tablets into 2 or more distinct layers:
a. mottling b. lamination c. capping
16. poorly manufactured tablets with small pinholes on the surface, this defect is called:
a. picking b. swating c. mottling d. lamination
17. the all glass container for SVP:
a. vials b. ampules c. bottles d. all
18. common component of cap liners, stoppers and parts of dropper assemblies:
a. glass b. rubber c. plastic d. metal
19. soda lime glass is also known as :
a. type I b. NP c. type III d. b & c
20. highly resistant borosilicate glass is also known as :
a. type I b. type II c. NP d. type III
21. film coating problem due to internal stress:
a. cracking b. lamination c. mottling d. roughness
22. rapid drying leads to the film coating problem:
a. blistering b. sweating c. flaking d. blooming
23. tyndallization is performed at:
a. 100 degrees at 30 min. b.120 degrees at 30 min c. any
24. the pressure required to push the air through a liquid saturated filter:
a. bubble point c. saturation point
b. flash point d. AOTA
25. common lubricant for tablets:
a. mannitol b. acacia c. magnesium stearate
26. the USP medicine dropper when held vertically delivers how many drops of water:
a. 15 drops b. 18 drops c. 25 drops d. 20 drops
27. the USP requirement for opthalmic preparation is:
a. sterility b. isotonicity c. clarity d. none
28. tablet excipients used to make a reasonably sized tablet:
a. binders b. diluents c. glidants d. disintegrants
29. filtration of a solution to as high degree of clarity:
a. polishing b. dialysis c. clarification d. dissolution
30. defect characterized by small pinholes on the surface of poorly manufactured tablets:
a. mottling b. picking c. capping d. compacting
31. container of choice for ointment, except:
a. glass b. jars c. tubes d. plastic
32. types of suppositories, except:
a. nasal b. vaginal c. rectal d.oral
33. general method of preparing ointments, except:
a. fusion b. mechanical c. comminution d. AOTA
34. the aseptic area in parenteral department is classified as:
a. class 500 b. class 100 c. class 10 d. class 50
35. areas of concern during production of parenteral include:
a. components c. production facilities
b. production procedures d. AOTA
36. functions of package/ packaging materials:
a. for information c. for presentation
b. for containment d. AOTA
37. the percentage allowance for error in high speed automatic filling machine:
a. 0.5%- 1.0 % b. 3.0 – 5.0 % c. 0.10 % d. 10-20 %
38. punches in tablet- making control:
a. size & shape b. color c. hardness d. solubility
39. suppositories which are administered vaginally:
a.pessaries b. bougies c. both d. none
40. to control raw material and finished products in the warehouse, the practice of:
a. FIFO b. LILO c. SQC d. AOTA
41. total quality means:
a. production is responsible for quality
b. QC strict adherence to standards
c. quality is everybody’s business
42. minimum satisfactory hardness of tablets:
a. 2 kg b. 3 kg. c. 4 kg d. 5 kg
43. rule of thumb is for testing:
a. compressed tablets c. hypodermic flow hood
b. ampules d. all
44. Standard operating procedure is:
a. done to facilitate recall c. concerned with record keeping
b. a step by step method on how to go about a job
45. smallest size for hard gelatin capsules is:
a. 000 b. #5 c. #3 d. #2
46. manufactured tanks of most pharmaceuticals liquids should be made of:
a. galvanized iron b. stainless steel c. glasswares
47. thicker & stiffer than ointment:
a. pastes b. creams c. suspensions d. emulsions
48. fastest form of route of administration:
a. tablets b. capsules c. parenterals d. syrups
49. bullet-shaped capsules are:
a. parvules b. pulvules c. ampules d. all
50. solid dosage form usually enclosed in a shell w/c vary in sizes:
a.tablets b. capsules c. pills d. troches


Set B: True or False
____1. sublingual tablet is placed beneath the tongue.
____2. oculentum is intended for use in the eye.
____3. capsules do not absorb moisture
____4. largest size of capsule is obtainable for use in veterinary purposes
____5. the commercially marketed caps appear in a pink & white color
____6. it was Murdoch who patented the 2 piece hard gelatin cap which is easier to
fill & close.
____7. the hand filled cap should not be tapped to avoid overflowing
____8. spans & tweens are called surfactants
--------9. pharmaceutical aerosol maybe in the form of spray
___10. content uniformity is carried out in 20 tabs/ caps.
___11. weight variation test is carried out in 10 tablets.
___12. water that is free from pyrogens is bacteriostatic water for injection
___13. HEPA filters are used for filtration of air.
___14. the practical way of testing the tablet is by the rule of thumb
___15. #5 is the biggest oral size capsule suitable for animals.
___16. #10 is the smallest oral size capsule intended for human being
___17. in ampule sealing, a tip sealing is characterized by a bead at the ampules
___18 tablet coating is one of the oldest arts employed by the pharmaceutical
industry
19- 21 . Three (3) capsule sizes suitable for veterinary purpose & @ content:

22-29 Eight ( 8 ) capsule sizes suitable for human being & @ content
30- 35. Seven(7) solubilty range/ parts:

36-39 Four (4) USP Sterilization Techniques

40- 45 Six ( 6) samples of a primary packaging materials

46-50 Five (5 ) samples of a secondary packaging materials.

Good luck!!